What the FDA labels say about taking them together

Rifampin and sufentanil

Sufentanil's FDA label of June 1, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name sufentanil. The sufentanil label: “The concomitant use of Sufentanil Citrate Injection and CYP3A4 inducers can decrease the plasma concentration of sufentanil, resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have …”

Check it at the source: the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.); the sufentanil FDA label on DailyMed (effective June 1, 2026, Hospira, Inc.).

What does the rifampin label say about sufentanil?

Rifampin's label (effective February 11, 2026) does not name sufentanil in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed

What does the sufentanil label say about rifampin?

Sufentanil label, drug interactions
CYP3A4 Inducers Clinical Impact: The concomitant use of Sufentanil Citrate Injection and CYP3A4 inducers can decrease the plasma concentration of sufentanil, resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to sufentanil. … Sufentanil Citrate Injection dosage reduction and monitor for signs of respiratory depression. Examples: Rifampin, carbamazepine, phenytoin

Sufentanil label, warnings and precautions
Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in Sufentanil Citrate Injection-treated patients may increase sufentanil plasma concentrations and prolong opioid adverse reactions.

Source: FDA drug label (Sufentanil Citrate), Hospira, Inc., effective June 1, 2026 (SPL set 20293943-46ff-4345-1aa4-929b4e017a25), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

13Rifampin generic labelers

1Sufentanil generic labelers

	Rifampin	Sufentanil
Labeled for	n/a	n/a
Boxed warning	No	Yes
Pharmacy cost (NADAC)	$0.679 per capsule 300 mg capsule	n/a
Shortage now	In shortage	In shortage

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?

Rifampin: the full record
Sufentanil: the full record
Check more medicines together: up to five at once