What the FDA labels say about taking them together
Rifampin and rilpivirine
Rilpivirine's FDA label of August 28, 2025 names rifampin in its contraindications section; the rifampin label PlainMeds reads does not name rilpivirine. The rilpivirine label: “Coadministration is contraindicated with EDURANT or EDURANT PED.”
Check it at the source: the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.); the rilpivirine FDA label on DailyMed (effective August 28, 2025, Janssen Products, LP).
What does the rifampin label say about rilpivirine?
Rifampin's label (effective February 11, 2026) does not name rilpivirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
What does the rilpivirine label say about rifampin?
Rilpivirine label, contraindicationsDrug Class: Antimycobacterials; Contraindicated Drugs in Class: Rifampin Rifapentine; Clinical Comment: Potential for significant decreases in rilpivirine plasma concentrations due to CYP3A enzyme induction, which may result in loss of virologic response.
Rilpivirine label, drug interactionsConcomitant Drug Class/Drug Name: Antimycobacterials: rifampin rifapentine; Effect on Concentration of Rilpivirine or Concomitant Drug: ↓ rilpivirine; Clinical Comment: Coadministration is contraindicated with EDURANT or EDURANT PED [see ].
Source: FDA drug label (EDURANT), Janssen Products, LP, effective August 28, 2025 (SPL set 03880372-2c68-45c6-a53a-f420c49541d6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Rifampin | Rilpivirine | |
|---|---|---|
| Labeled for | n/a | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.679 per capsule 300 mg capsule | $48.04 per tablet 25 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once