What the FDA labels say about taking them together
Caspofungin and rifampin
Caspofungin's FDA label of October 11, 2024 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name caspofungin. The caspofungin label: “Inducers of Hepatic CYP Enzymes Rifampin: Rifampin is a potent CYP3A4 inducer and concomitant administration with CANCIDAS is expected to reduce the plasma concentrations of CANCIDAS.”
Check it at the source: the caspofungin FDA label on DailyMed (effective October 11, 2024, Merck Sharp & Dohme LLC); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the caspofungin label say about rifampin?
Caspofungin label, drug interactionsInducers of Hepatic CYP Enzymes Rifampin: Rifampin is a potent CYP3A4 inducer and concomitant administration with CANCIDAS is expected to reduce the plasma concentrations of CANCIDAS.
Source: FDA drug label (Caspofungin Acetate, NDA206110), Fresenius Kabi USA, LLC, effective January 8, 2026 (SPL set e76d8d83-3691-451c-a32c-d91448c54d16), via openFDA
Source: FDA drug label (CANCIDAS), Merck Sharp & Dohme LLC, effective October 11, 2024 (SPL set 3bad23a6-09a6-4194-9182-093ed61bc71c), via openFDA; the full label on DailyMed
What does the rifampin label say about caspofungin?
Rifampin's label (effective February 11, 2026) does not name caspofungin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Caspofungin | Rifampin | |
|---|---|---|
| Labeled for | Fungal infections | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.679 per capsule 300 mg capsule |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once