What the FDA labels say about taking them together
Resmetirom and simvastatin
Resmetirom's FDA label of July 29, 2026 names simvastatin in its drug interactions section; the simvastatin label PlainMeds reads does not name resmetirom. The resmetirom label: “Clinical Impact; REZDIFFRA increased plasma concentrations of some statins, which may increase the risk of adverse reactions related to these drugs.”
Check it at the source: the resmetirom FDA label on DailyMed (effective July 29, 2026, Madrigal Pharmaceuticals, Inc.); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the resmetirom label say about simvastatin?
Resmetirom label, drug interactionsClinical Impact; REZDIFFRA increased plasma concentrations of some statins (atorvastatin, pravastatin, rosuvastatin and simvastatin) [see ], which may increase the risk of adverse reactions related to these drugs.
Resmetirom label, warnings and precautionsInteraction with Certain Statins An increase in exposure of atorvastatin, pravastatin, rosuvastatin and simvastatin was observed when concomitantly administered with REZDIFFRA [see Clinical Pharmacology (12.3) ], which may increase the risk of adverse reactions related to these drugs.
Source: FDA drug label (REZDIFFRA), Madrigal Pharmaceuticals, Inc., effective July 29, 2026 (SPL set e67ea09f-a840-439c-86c8-f98585f978b2), via openFDA; the full label on DailyMed
What does the simvastatin label say about resmetirom?
Simvastatin's label (effective March 28, 2025) does not name resmetirom in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Resmetirom | Simvastatin | |
|---|---|---|
| Labeled for | n/a | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.0321 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once