What the FDA labels say about taking them together
Niacin and repaglinide
Repaglinide's FDA label of May 2, 2025 names niacin in its drug interactions section; the niacin label PlainMeds reads does not name repaglinide. The repaglinide label: “… antagonists, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens, protease inhibitors, somatropin, sympathomimetic agents, and thyroid hormones.”
Check it at the source: the niacin FDA label on DailyMed (effective February 14, 2023, Aurobindo Pharma Limited); the repaglinide FDA label on DailyMed (effective May 2, 2025, Chartwell RX, LLC).
What does the niacin label say about repaglinide?
Niacin's label (effective February 14, 2023) does not name repaglinide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Niacin), Aurobindo Pharma Limited, effective February 14, 2023 (SPL set 43233a21-3f90-4c69-bbeb-f50d5f2d35ae), via openFDA; the full label on DailyMed
What does the repaglinide label say about niacin?
Repaglinide label, drug interactionsDrugs That May Decrease the Blood Glucose Lowering Effect of Repaglinide Tablets Intervention: Repaglinide tablets dose increases and increased frequency of glucose monitoring may be required when co-administered. Examples: Atypical antipsychotics (e.g., olanzapine and clozapine), calcium channel antagonists, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones.
Source: FDA drug label (Repaglinide), Chartwell RX, LLC, effective May 2, 2025 (SPL set cb995e92-295e-4638-a064-978211f5afe1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Niacin | Repaglinide | |
|---|---|---|
| Labeled for | High cholesterol, Heart attack and coronary artery disease, High triglycerides | Type 2 diabetes |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.193 per tablet 500 mg tablet | $0.0987 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once