What the FDA labels say about taking them together
Ranolazine and tacrolimus
Ranolazine's FDA label of January 23, 2026 names tacrolimus in its drug interactions section; the tacrolimus labels PlainMeds reads (4) do not name ranolazine. The ranolazine label: “Doses of other sensitive CYP3A substrates (e.g., lovastatin) and CYP3A substrates with narrow therapeutic range may need to be reduced with ranolazine.”
Check it at the source: the ranolazine FDA label on DailyMed (effective January 23, 2026, Glenmark Pharmaceuticals Inc., USA); the tacrolimus FDA label on DailyMed (effective July 17, 2026, Stellon Biotech Inc.).
What does the ranolazine label say about tacrolimus?
Ranolazine label, drug interactionsDoses of other sensitive CYP3A substrates (e.g., lovastatin) and CYP3A substrates with narrow therapeutic range (e.g., cyclosporine, tacrolimus, sirolimus) may need to be reduced with ranolazine.
Source: FDA drug label (Aspruzyo Sprinkle, NDA216018), SUN PHARMACEUTICAL INDUSTRIES, INC., effective January 29, 2025 (SPL set dd9f81e4-50da-4551-aed5-559d304df42e), via openFDA
Source: FDA drug label (Ranolazine), Glenmark Pharmaceuticals Inc., USA, effective January 23, 2026 (SPL set 0cf58732-c242-49b0-8e3f-248778b4458d), via openFDA; the full label on DailyMed
What does the tacrolimus label say about ranolazine?
Tacrolimus's label (effective July 17, 2026) and its 3 other brand-application labels do not name ranolazine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tacrolimus), Stellon Biotech Inc., effective July 17, 2026 (SPL set 6b89e8a4-9f11-42e3-8e79-fe617e7c461f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ranolazine | Tacrolimus | |
|---|---|---|
| Labeled for | Angina | Organ transplant rejection, Eczema (atopic dermatitis) |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.165 per tablet 500 mg tablet | $0.970 per gram 0.1% ointment |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once