What the FDA labels say about taking them together
Ranitidine and rilpivirine
Rilpivirine's FDA label of August 28, 2025 names ranitidine in its drug interactions section; the ranitidine label PlainMeds reads does not name rilpivirine. The rilpivirine label: “The combination of EDURANT or EDURANT PED and H 2 -receptor antagonists should be used with caution as coadministration may cause significant decreases in rilpivirine plasma concentrations (increase in gastric pH). …”
Check it at the source: the ranitidine FDA label on DailyMed (effective May 1, 2026, Amneal Pharmaceuticals of New York LLC); the rilpivirine FDA label on DailyMed (effective August 28, 2025, Janssen Products, LP).
What does the ranitidine label say about rilpivirine?
Ranitidine's label (effective May 1, 2026) does not name rilpivirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ranitidine), Amneal Pharmaceuticals of New York LLC, effective May 1, 2026 (SPL set b38a3332-5c54-453f-aeb7-070f830955c2), via openFDA; the full label on DailyMed
What does the rilpivirine label say about ranitidine?
Rilpivirine label, drug interactionsConcomitant Drug Class/Drug Name: H 2 -Receptor Antagonists: cimetidine famotidine nizatidine ranitidine; Effect on Concentration of Rilpivirine or Concomitant Drug: ↔ rilpivirine (famotidine taken 12 hours before rilpivirine or 4 hours after rilpivirine); Clinical Comment: The combination of EDURANT or EDURANT PED and H 2 -receptor antagonists should be used with caution as coadministration may cause significant decreases in rilpivirine plasma concentrations (increase in gastric pH). H 2 -receptor antagonists should only be administered at least 12 hours before or at least 4 hours after EDURANT or EDURANT PED.
Source: FDA drug label (EDURANT), Janssen Products, LP, effective August 28, 2025 (SPL set 03880372-2c68-45c6-a53a-f420c49541d6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ranitidine | Rilpivirine | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $48.04 per tablet 25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once