What the FDA labels say about taking them together
Ramipril and temsirolimus
Ramipril's FDA label of August 24, 2026 names temsirolimus in its drug interactions section, and temsirolimus's label names ramipril too. The ramipril label: “Patients taking concomitant mammalian target of rapamycin (mTOR) inhibitor (e.g. temsirolimus) therapy or a neprilysin inhibitor may be at increased risk for angioedema.”
Check it at the source: the ramipril FDA label on DailyMed (effective August 24, 2026, Lupin Pharmaceuticals, Inc.); the temsirolimus FDA label on DailyMed (effective December 26, 2025, Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.).
What does the ramipril label say about temsirolimus?
Ramipril label, drug interactions7.7 mTOR Inhibitors or Other Drugs Known to Cause Angioedema Patients taking concomitant mTOR inhibitor (e.g. temsirolimus) therapy or a neprilysin inhibitor may be at increased risk for angioedema [see WARNINGS AND PRECAUTIONS ( 5.1 )].
Ramipril label, warnings and precautionsPatients taking concomitant mammalian target of rapamycin (mTOR) inhibitor (e.g. temsirolimus) therapy or a neprilysin inhibitor may be at increased risk for angioedema [see DRUG INTERACTIONS ( 7.7 )].
Source: FDA drug label (Ramipril), Lupin Pharmaceuticals, Inc., effective August 24, 2026 (SPL set a8cdec12-81d1-4ef4-82c0-d05d93c37a07), via openFDA; the full label on DailyMed
What does the temsirolimus label say about ramipril?
Temsirolimus label, drug interactionsAngioedema with ACE inhibitors and Calcium Channel Blockers Angioedema has been reported in patients taking mammalian target of rapamycin (mTOR) inhibitors in combination with ramipril and/or amlodipine.
Source: FDA drug label (Torisel), NDA022088 (Pf Prism Cv), as published by Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., effective December 26, 2025 (SPL set 95b7dc92-2180-42f1-8699-3c28f609e674), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ramipril | Temsirolimus | |
|---|---|---|
| Labeled for | High blood pressure, Heart attack and coronary artery disease | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0707 per capsule 10 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once