What the FDA labels say about taking them together
Raltegravir and rifampin
Raltegravir's FDA label of October 18, 2024 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name raltegravir. The raltegravir label: “Coadministration of ISENTRESS or ISENTRESS HD with drugs that are strong inducers of UGT1A1, such as rifampin, may result in reduced plasma concentrations of raltegravir.”
Check it at the source: the raltegravir FDA label on DailyMed (effective October 18, 2024, Merck Sharp & Dohme LLC); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the raltegravir label say about rifampin?
Raltegravir label, drug interactionsCoadministration of ISENTRESS or ISENTRESS HD with drugs that are strong inducers of UGT1A1, such as rifampin, may result in reduced plasma concentrations of raltegravir ( 2.1 , 7.1 ).
Source: FDA drug label (ISENTRESS), Merck Sharp & Dohme LLC, effective October 18, 2024 (SPL set 89a5ec53-d956-4329-8004-0f40f51c88a3), via openFDA; the full label on DailyMed
What does the rifampin label say about raltegravir?
Rifampin's label (effective February 11, 2026) does not name raltegravir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Raltegravir | Rifampin | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $34.54 per tablet 400 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once