What the FDA labels say about taking them together
Quinine and sodium bicarbonate
Quinine's FDA label of November 9, 2023 names sodium bicarbonate in its drug interactions (prescription label) section; the sodium bicarbonate labels PlainMeds reads (3) do not name quinine. The quinine label: “Urinary Alkalizers Urinary alkalinizing agents may increase plasma quinine concentrations.”
Check it at the source: the quinine FDA label on DailyMed (effective November 9, 2023); the sodium bicarbonate FDA label on DailyMed (effective August 4, 2026).
What does the quinine label say about sodium bicarbonate?
Quinine label, drug interactions (prescription label)Urinary Alkalizers (Acetazolamide, Sodium Bicarbonate) Urinary alkalinizing agents may increase plasma quinine concentrations.
Source: FDA drug label (Chininum sulphuricum), Boiron, effective November 9, 2023 (SPL set 33885950-2a55-11e7-8288-424c58303031), via openFDA; the full label on DailyMed
What does the sodium bicarbonate label say about quinine?
Sodium bicarbonate's label (effective August 4, 2026) and its 2 other brand-application labels do not name quinine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Sodium Bicarbonate 5 gr), TWIN MED LLC, effective August 4, 2026 (SPL set e325d899-d9a6-5adb-e053-2995a90ac861), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Quinine | Sodium bicarbonate | |
|---|---|---|
| Labeled for | n/a | Acid reflux and ulcers, Diarrhea |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.698 per capsule 324 mg capsule | $0.154 per mL 8.4% vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once