What the FDA labels say about taking them together
Quinine and simvastatin
Quinine's FDA label of November 9, 2023 names simvastatin in its drug interactions (prescription label) section; the simvastatin label PlainMeds reads does not name quinine.
Check it at the source: the quinine FDA label on DailyMed (effective November 9, 2023); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the quinine label say about simvastatin?
Quinine label, drug interactions (prescription label)Thus, clinicians considering combined therapy of quinine sulfate with atorvastatin or other HMG-CoA reductase inhibitors ("statins") that are CYP3A4 substrates (e.g., simvastatin, lovastatin) should carefully weigh the potential benefits and risks of each medication.
Source: FDA drug label (Chininum sulphuricum), Boiron, effective November 9, 2023 (SPL set 33885950-2a55-11e7-8288-424c58303031), via openFDA; the full label on DailyMed
What does the simvastatin label say about quinine?
Simvastatin's label (effective March 28, 2025) does not name quinine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Quinine | Simvastatin | |
|---|---|---|
| Labeled for | n/a | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.698 per capsule 324 mg capsule | $0.0321 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once