What the FDA labels say about taking them together
Pyridostigmine and succinylcholine
Pyridostigmine's FDA label (Pyridostigmine Bromide) of December 23, 2025 names succinylcholine in its drug interactions section; the succinylcholine labels PlainMeds reads (2) do not name pyridostigmine.
Check it at the source: the pyridostigmine FDA label on DailyMed (effective December 2, 2020, Bausch Health US, LLC); the succinylcholine FDA label on DailyMed (effective August 18, 2026, Hospira, Inc.).
What does the pyridostigmine label say about succinylcholine?
Pyridostigmine Bromide label (Surgeon General-Department of the Army (TSG-DA), December 23, 2025), drug interactionsDrugs that Interfere with Neuromuscular Transmission Particular caution should be observed in the administration of depolarizing neuromuscular blocking agents (e.g., succinylcholine) during surgery since the degree of neuromuscular blockade that ensues may be enhanced by previously administered pyridostigmine bromide.
Source: FDA drug label (Pyridostigmine Bromide, NDA020414), Surgeon General-Department of the Army (TSG-DA), effective December 23, 2025 (SPL set 0b296555-c32f-42db-b5f3-ea981a3dd2f8), via openFDA
Source: FDA drug label (Mestinon), Bausch Health US, LLC, effective December 2, 2020 (SPL set a851795e-b7a8-40c3-9922-5e79d3eb4d92), via openFDA; the full label on DailyMed
What does the succinylcholine label say about pyridostigmine?
Succinylcholine's label (effective August 18, 2026) and its 1 other brand-application label do not name pyridostigmine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (QUELICIN), Hospira, Inc., effective August 18, 2026 (SPL set fb08161e-7711-406d-e7b3-ea4515c07983), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pyridostigmine | Succinylcholine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.249 per tablet 60 mg tablet | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once