What the FDA labels say about taking them together
Pseudoephedrine and selegiline
Selegiline's FDA label (Emsam) of May 15, 2020 names pseudoephedrine in its drug interactions section; pseudoephedrine's label does not name selegiline itself but warns about its class (MAO inhibitors). The selegiline label: “Therefore, monitor blood pressure if EMSAM is used with any of the following drugs: buspirone, amphetamines, and cold products or weight-reducing preparations that contain sympathomimetic amines.”
Check it at the source: the pseudoephedrine FDA label on DailyMed (effective October 30, 2025, L. Perrigo Company); the selegiline FDA label on DailyMed (effective August 7, 2024, Rising Pharma Holdings, Inc.).
What does the pseudoephedrine label say about selegiline?
Pseudoephedrine's label does not name selegiline itself; it warns about its class (MAO inhibitors):
Pseudoephedrine label, warningsWarnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug.
Pseudoephedrine label, warningsIf you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Source: FDA drug label (Good Sense Suphedrine 12 Hour), L. Perrigo Company, effective October 30, 2025 (SPL set 1de8a7f6-e7bb-437d-8794-c4b9f43b89c9), via openFDA; the full label on DailyMed
What does the selegiline label say about pseudoephedrine?
Emsam label (Viatris Specialty LLC, May 15, 2020), drug interactionsTherefore, monitor blood pressure if EMSAM is used with any of the following drugs: buspirone, amphetamines, and cold products or weight-reducing preparations that contain sympathomimetic amines (e.g., pseudoephedrine, phenylephrine, phenylpropanolamine, and ephedrine).
Emsam label (Viatris Specialty LLC, May 15, 2020), warnings and precautionsBlood Pressure Elevation Related to Concomitant Medication: monitor blood pressure if EMSAM is used with any of the following drugs: buspirone, amphetamines, or cold products or weight-reducing preparations that contain sympathomimetic amines (e.g., pseudoephedrine, phenylephrine, phenylpropanolamine, and ephedrine).
Source: FDA drug label (Emsam, NDA021336), Viatris Specialty LLC, effective May 15, 2020 (SPL set b891bd9f-fdb8-4862-89c5-ecdd700398a3), via openFDA
Source: FDA drug label (Selegiline Hydrochloride), Rising Pharma Holdings, Inc., effective August 7, 2024 (SPL set 23c4481f-d150-40c6-addb-b3e454ca914f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pseudoephedrine | Selegiline | |
|---|---|---|
| Labeled for | Cough and cold | Parkinson's disease, Depression |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.281 per tablet 120 mg tablet | $0.756 per capsule 5 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once