What the FDA labels say about taking them together
Propofol and succinylcholine
Propofol's FDA label of September 11, 2025 names succinylcholine in its drug interactions section; the succinylcholine labels PlainMeds reads (2) do not name propofol. The propofol label: “The intravenous administration of anticholinergic agents should be considered to modify potential increases in vagal tone due to concomitant agents (e.g., succinylcholine) or surgical stimuli.”
Check it at the source: the propofol FDA label on DailyMed (effective September 11, 2025, Fresenius Kabi USA, LLC); the succinylcholine FDA label on DailyMed (effective August 18, 2026, Hospira, Inc.).
What does the propofol label say about succinylcholine?
Propofol label, drug interactionsCommon Neuromuscular Blocking Agents DIPRIVAN does not cause a clinically significant change in onset, intensity or duration of action of the commonly used neuromuscular blocking agents (e.g., succinylcholine and nondepolarizing muscle relaxants).
Propofol label, warnings and precautionsThe intravenous administration of anticholinergic agents (e.g., atropine or glycopyrrolate) should be considered to modify potential increases in vagal tone due to concomitant agents (e.g., succinylcholine) or surgical stimuli.
Source: FDA drug label (Diprivan), Fresenius Kabi USA, LLC, effective September 11, 2025 (SPL set e3105799-a4b6-f3f4-e6e2-b2b29bbdb538), via openFDA; the full label on DailyMed
What does the succinylcholine label say about propofol?
Succinylcholine's label (effective August 18, 2026) and its 1 other brand-application label do not name propofol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (QUELICIN), Hospira, Inc., effective August 18, 2026 (SPL set fb08161e-7711-406d-e7b3-ea4515c07983), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Propofol | Succinylcholine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.171 per mL 200 mg/20 mL vial | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once