Propafenone and Desipramine Interaction
Drug interaction information between Propafenone and Desipramine.
Propafenone and Desipramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Propafenone and Desipramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Desipramine blocks the enzymes that usually break down propafenone, which can increase the amount of medicine in your system.
FDA Label Information
(7.6) 7.1 CYP2D6 and CYP3A4 Inhibitors Drugs that inhibit CYP2D6 (such as desipramine, paroxetine, ritonavir, sertraline) and CYP3A4 (such as ketoconazole, ritonavir, saquinavir, erythromycin, grapefruit juice) can be expected to cause increased plasma levels of propafenone.
Propafenone Also Interacts With
- Nirmatrelvir/Ritonavir major
- Amiodarone moderate
- Fluoxetine moderate
- Nebivolol moderate
- Ketoconazole minor
Desipramine Also Interacts With
- Atomoxetine minor
- Bupropion minor
- Darunavir minor
- Desvenlafaxine minor
- Dopamine minor
Frequently Asked Questions
What SPL severity band is on file for Propafenone + Desipramine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propafenone has 26 labeled pairs on file vs Desipramine's 18. In the minor band specifically: Propafenone has 22 (also Ketoconazole, Erythromycin, Cimetidine, Amitriptyline); Desipramine has 18 (also Atomoxetine, Bupropion, Darunavir, Desvenlafaxine).
What mechanism field is on file for Propafenone and Desipramine?
Desipramine blocks the enzymes that usually break down propafenone, which can increase the amount of medicine in your system.
Propafenone carries more major-labeled pairs than Desipramine
SPL source-record counts only. This page's band is minor · classes on file: Propafenone (Class IC Antiarrhythmic); Desipramine (Tricyclic Antidepressant (TCA)).
Propafenone has 1 major-labeled pair vs Desipramine's 0. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 22 minor · 26 total
- Other minor peers for Propafenone
- Ketoconazole
- Erythromycin
- Cimetidine
- Amitriptyline
0 major · 0 moderate · 18 minor · 18 total
- Other minor peers for Desipramine
- Atomoxetine
- Bupropion
- Darunavir
- Desvenlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.