Propafenone and Cimetidine Interaction
Drug interaction information between Propafenone and Cimetidine.
Propafenone and Cimetidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Propafenone and Cimetidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cimetidine changes how your body handles propafenone, which can cause the levels of propafenone in your blood to rise.
FDA Label Information
Cimetidine Concomitant administration of propafenone immediate-release tablets and cimetidine in 12 healthy subjects resulted in a 20% increase in steady-state plasma concentrations of propafenone.
Propafenone Also Interacts With
- Nirmatrelvir/Ritonavir major
- Amiodarone moderate
- Fluoxetine moderate
- Nebivolol moderate
- Ketoconazole minor
Cimetidine Also Interacts With
- Levofloxacin major
- Posaconazole major
- Risperidone major
- Valproate major
- Empagliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Propafenone + Cimetidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Propafenone's 26. In the minor band specifically: Propafenone has 22 (also Ketoconazole, Erythromycin, Desipramine, Amitriptyline); Cimetidine has 63 (also Albendazole, Alogliptin, Alosetron, Alprazolam).
What mechanism field is on file for Propafenone and Cimetidine?
Cimetidine changes how your body handles propafenone, which can cause the levels of propafenone in your blood to rise.
Cimetidine carries more major-labeled pairs than Propafenone
SPL source-record counts only. This page's band is minor · classes on file: Propafenone (Class IC Antiarrhythmic); Cimetidine (H2 Receptor Antagonist).
Cimetidine has 4 major-labeled pairs vs Propafenone's 1. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 22 minor · 26 total
- Other minor peers for Propafenone
- Ketoconazole
- Erythromycin
- Desipramine
- Amitriptyline
4 major · 10 moderate · 63 minor · 77 total
- Other minor peers for Cimetidine
- Albendazole
- Alogliptin
- Alosetron
- Alprazolam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.