What the FDA labels say about taking them together
Procainamide and rocuronium
Rocuronium's FDA label of July 16, 2025 names procainamide in its drug interactions section; the procainamide label PlainMeds reads does not name rocuronium. The rocuronium label: “… anesthetics, certain antibiotics, quinidine, magnesium, lithium, local anesthetics, procainamide Reduced rocuronium bromide activity possible:”
Check it at the source: the procainamide FDA label on DailyMed (effective February 17, 2025, Caplin Steriles Limited); the rocuronium FDA label on DailyMed (effective July 16, 2025, Fresenius Kabi USA, LLC).
What does the procainamide label say about rocuronium?
Procainamide's label (effective February 17, 2025) does not name rocuronium in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Procainamide Hydrochloride), Caplin Steriles Limited, effective February 17, 2025 (SPL set fcaa5e9a-3c8a-4796-aa87-626268b6cf60), via openFDA; the full label on DailyMed
What does the rocuronium label say about procainamide?
Rocuronium label, drug interactionsInhalation anesthetics ( 7.3 ), certain antibiotics ( 7.1 ), quinidine ( 7.10 ), magnesium ( 7.6 ), lithium ( 7.4 ), local anesthetics ( 7.5 ), procainamide ( 7.8 ) Reduced Rocuronium Bromide Injection activity possible:
Rocuronium label, warnings and precautionsCertain inhalation anesthetics, particularly enflurane and isoflurane, antibiotics, magnesium salts, lithium, local anesthetics, procainamide, and quinidine have been shown to increase the duration of neuromuscular block and decrease infusion requirements of neuromuscular blocking agents [see Drug Interactions ( 7.3 )].
Source: FDA drug label (Rocuronium Bromide, NDA219108), B. Braun Medical Inc., effective July 17, 2026 (SPL set a54a79f7-5207-43d8-a139-7d57557caa50), via openFDA
Source: FDA drug label (Rocuronium), Fresenius Kabi USA, LLC, effective July 16, 2025 (SPL set 9a622308-7bda-4ca0-9de5-d6b3b4be3384), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Procainamide | Rocuronium | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once