What the FDA labels say about taking them together
Probenecid/sulopenem etzadroxil and valproic acid
Probenecid/sulopenem etzadroxil's FDA label of December 6, 2025 names valproic acid in its drug interactions section; the valproic acid label PlainMeds reads does not name probenecid/sulopenem etzadroxil. The probenecid/sulopenem etzadroxil label: “Valproic Acid No valproic acid dosage adjustment is recommended when used concomitantly with ORLYNVAH.”
Check it at the source: the probenecid/sulopenem etzadroxil FDA label on DailyMed (effective December 6, 2025, ITERUM THERAPEUTICS US LIMITED); the valproic acid FDA label on DailyMed (effective January 24, 2025, PAI Holdings, LLC dba PAI Pharma).
What does the probenecid/sulopenem etzadroxil label say about valproic acid?
Probenecid/sulopenem etzadroxil label, drug interactionsValproic Acid No valproic acid dosage adjustment is recommended when used concomitantly with ORLYNVAH.
Source: FDA drug label (ORLYNVAH), ITERUM THERAPEUTICS US LIMITED, effective December 6, 2025 (SPL set 24c451c0-4cfb-37f3-e063-6394a90a895e), via openFDA; the full label on DailyMed
What does the valproic acid label say about probenecid/sulopenem etzadroxil?
Valproic acid's label (effective January 24, 2025) does not name probenecid/sulopenem etzadroxil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VALPROIC ACID), PAI Holdings, LLC dba PAI Pharma, effective January 24, 2025 (SPL set 7d5cb52e-37dd-4dfa-a6f4-09f9548846c6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Probenecid/sulopenem etzadroxil | Valproic acid | |
|---|---|---|
| Labeled for | Urinary tract infections | Seizures and epilepsy, Migraine |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.243 per capsule 250 mg capsule |
| Shortage now | No current entry | Listed; available |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once