What the FDA labels say about taking them together
Probenecid/sulopenem etzadroxil and tromethamine
Probenecid/sulopenem etzadroxil's FDA label of December 6, 2025 names tromethamine in its contraindications section; the tromethamine label PlainMeds reads does not name probenecid/sulopenem etzadroxil. The probenecid/sulopenem etzadroxil label: “Contraindicated”
Check it at the source: the probenecid/sulopenem etzadroxil FDA label on DailyMed (effective December 6, 2025, ITERUM THERAPEUTICS US LIMITED); the tromethamine FDA label on DailyMed (effective May 27, 2026, Hospira, Inc.).
What does the probenecid/sulopenem etzadroxil label say about tromethamine?
Probenecid/sulopenem etzadroxil label, contraindicationsKnown uric acid kidney stones [see Warnings and Precautions ( 5.3 )] Concomitant use of ORLYNVAH and ketorolac tromethamine is contraindicated [see Drug Interactions ( 7.1 )] Patients with a history of hypersensitivity to the components of ORLYNVAH (sulopenem etzadroxil and probenecid) or other beta- lactam antibacterial drugs. ( 4 ) Patients with known uric acid kidney stones. ( 4 ) Concomitant use of ORLYNVAH and ketorolac tromethamine is contraindicated.
Probenecid/sulopenem etzadroxil label, drug interactionsConcomitant Drug/Drug Class: Ketorolac tromethamine; Effect on Drug Concentration: ↑ ketorolac tromethamine; Recommendation: Contraindicated
Source: FDA drug label (ORLYNVAH), ITERUM THERAPEUTICS US LIMITED, effective December 6, 2025 (SPL set 24c451c0-4cfb-37f3-e063-6394a90a895e), via openFDA; the full label on DailyMed
What does the tromethamine label say about probenecid/sulopenem etzadroxil?
Tromethamine's label (effective May 27, 2026) does not name probenecid/sulopenem etzadroxil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (THAM), Hospira, Inc., effective May 27, 2026 (SPL set 4af52118-c12b-4ad5-30bb-959848357e8a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Probenecid/sulopenem etzadroxil | Tromethamine | |
|---|---|---|
| Labeled for | Urinary tract infections | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once