What the FDA labels say about taking them together
Probenecid/sulopenem etzadroxil and rifampin
Probenecid/sulopenem etzadroxil's FDA label of December 6, 2025 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name probenecid/sulopenem etzadroxil. The probenecid/sulopenem etzadroxil label: “Monitor more frequently for adverse reactions associated with rifampin as recommended in its prescribing information.”
Check it at the source: the probenecid/sulopenem etzadroxil FDA label on DailyMed (effective December 6, 2025, ITERUM THERAPEUTICS US LIMITED); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the probenecid/sulopenem etzadroxil label say about rifampin?
Probenecid/sulopenem etzadroxil label, drug interactionsConcomitant Drug/Drug Class: Rifampin; Effect on Drug Concentration: ↑ rifampin; Recommendation: Monitor more frequently for adverse reactions associated with rifampin as recommended in its prescribing information.
Source: FDA drug label (ORLYNVAH), ITERUM THERAPEUTICS US LIMITED, effective December 6, 2025 (SPL set 24c451c0-4cfb-37f3-e063-6394a90a895e), via openFDA; the full label on DailyMed
What does the rifampin label say about probenecid/sulopenem etzadroxil?
Rifampin's label (effective February 11, 2026) does not name probenecid/sulopenem etzadroxil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Probenecid/sulopenem etzadroxil | Rifampin | |
|---|---|---|
| Labeled for | Urinary tract infections | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once