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What the FDA labels say about taking them together

Pravastatin and teriflunomide

Teriflunomide's FDA label of February 20, 2026 names pravastatin in its drug interactions section; the pravastatin label PlainMeds reads does not name teriflunomide. The teriflunomide label: “For other substrates of BCRP (e.g., mitoxantrone) and drugs in the OATP family, especially HMG-Co reductase inhibitors, consider reducing the dose of these drugs and monitor patients closely for signs and symptoms of …”

Check it at the source: the pravastatin FDA label on DailyMed (effective July 31, 2026, Apotex Corp.); the teriflunomide FDA label on DailyMed (effective February 20, 2026, Genzyme Corporation).

What does the pravastatin label say about teriflunomide?

Pravastatin's label (effective July 31, 2026) does not name teriflunomide in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (PRAVASTATIN SODIUM), Apotex Corp., effective July 31, 2026 (SPL set dcf45e4f-b46e-6fbb-b67a-2ff619ab1780), via openFDA; the full label on DailyMed

What does the teriflunomide label say about pravastatin?

Teriflunomide label, drug interactions

For other substrates of BCRP (e.g., mitoxantrone) and drugs in the OATP family (e.g., methotrexate, rifampin), especially HMG-Co reductase inhibitors (e.g., atorvastatin, nateglinide, pravastatin, repaglinide, and simvastatin), consider reducing the dose of these drugs and monitor patients closely for signs and symptoms of increased exposures to the drugs while patients are taking AUBAGIO [see Clinical Pharmacology (12.3) ].

Source: FDA drug label (Aubagio), NDA202992 (Sanofi Aventis Us), as published by Genzyme Corporation, effective February 20, 2026 (SPL set 4650d12c-b9c8-4525-b07f-a2d773eca155), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

37Pravastatin generic labelers
15Teriflunomide generic labelers
PravastatinTeriflunomide
Labeled forHeart attack and coronary artery disease, High cholesterol, High triglyceridesMultiple sclerosis
Boxed warningNoYes
Pharmacy cost (NADAC)$0.058 per tablet 20 mg tablet$0.233 per tablet 14 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?