What the FDA labels say about taking them together
Heparin and prasugrel
Prasugrel's FDA label of February 11, 2025 names heparin in its boxed warning section; the heparin labels PlainMeds reads (4) do not name prasugrel. The prasugrel label: “Additional risk factors for bleeding include: body weight <60 kg; propensity to bleed; concomitant use of medications that increase the risk of bleeding.”
Check it at the source: the heparin FDA label on DailyMed (effective November 28, 2025, Fresenius Kabi USA, LLC); the prasugrel FDA label on DailyMed (effective February 11, 2025, Panacea Biotec Limited).
What does the heparin label say about prasugrel?
Heparin's label (effective November 28, 2025) and its 3 other brand-application labels do not name prasugrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Heparin Sodium), Fresenius Kabi USA, LLC, effective November 28, 2025 (SPL set d55b4a63-0c04-4874-b74f-9e9b9e8b008c), via openFDA; the full label on DailyMed
What does the prasugrel label say about heparin?
Prasugrel label, boxed warningAdditional risk factors for bleeding include: body weight <60 kg; propensity to bleed; concomitant use of medications that increase the risk of bleeding (e.g., warfarin, heparin, fibrinolytic therapy, chronic use of non-steroidal anti-inflammatory drugs [NSAIDs]) [see Warnings and Precautions ( 5.1 )].
Prasugrel label, drug interactionsPrasugrel tablets can be administered with aspirin (75 mg to 325 mg per day), heparin, GPIIb/IIIa inhibitors, statins, digoxin, and drugs that elevate gastric pH, including proton pump inhibitors and H 2 blockers [see Clinical Pharmacology ( 12.3 )].
Prasugrel label, warnings and precautionsAspirin and heparin were commonly used in TRITON-TIMI 38 [see Drug Interactions ( 7.1 , 7.2 , 7.4 ), and Clinical Studies ( 14 )].
Source: FDA drug label (Effient, NDA022307), Cosette Pharmaceuticals, Inc., effective September 7, 2022 (SPL set 69ea2d58-5353-4222-b61f-cab976fa7e5e), via openFDA
Source: FDA drug label (PRASUGREL), Panacea Biotec Limited, effective February 11, 2025 (SPL set 944c195a-de24-a44c-8baa-84b624b5ddcb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Heparin | Prasugrel | |
|---|---|---|
| Labeled for | Blood clots (DVT and PE), Atrial fibrillation | Heart attack and coronary artery disease, Angina |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.18 per mL 5,000 unit/mL vial | $0.263 per tablet 10 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once