What the FDA labels say about taking them together
Pralidoxime and pyridostigmine
Pyridostigmine's FDA label (Pyridostigmine Bromide) of December 23, 2025 names pralidoxime in its boxed warning section; the pralidoxime label PlainMeds reads does not name pyridostigmine. The pyridostigmine label: “RISKS WITH IMPROPER USE OF PYRIDOSTIGMINE BROMIDE After Exposure to Soman, Use Atropine and Pralidoxime Pyridostigmine bromide is for use as a pretreatment for exposure to soman nerve agent.”
Check it at the source: the pralidoxime FDA label on DailyMed (effective April 1, 2026, Baxter Healthcare Corporation); the pyridostigmine FDA label on DailyMed (effective December 2, 2020, Bausch Health US, LLC).
What does the pralidoxime label say about pyridostigmine?
Pralidoxime's label (effective April 1, 2026) does not name pyridostigmine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Protopam Chloride), Baxter Healthcare Corporation, effective April 1, 2026 (SPL set 2741d8fd-51c2-46be-880b-99f2b20a6137), via openFDA; the full label on DailyMed
What does the pyridostigmine label say about pralidoxime?
Pyridostigmine Bromide label (Surgeon General-Department of the Army (TSG-DA), December 23, 2025), boxed warningRISKS WITH IMPROPER USE OF PYRIDOSTIGMINE BROMIDE After Exposure to Soman, Use Atropine and Pralidoxime Pyridostigmine bromide is for use as a pretreatment for exposure to soman nerve agent.
Pyridostigmine Bromide label (Surgeon General-Department of the Army (TSG-DA), December 23, 2025), warnings and precautionsUse of Pyridostigmine Bromide Risk of Not Stopping Pyridostigmine Bromide and Using Atropine and Pralidoxime in the Event of Soman Exposure Pyridostigmine bromide is for use as pretreatment for exposure to soman nerve agent and must not be taken after exposure to soman nerve agent [see Dosage and Administration (2.1 , 2.2) ].
Source: FDA drug label (Pyridostigmine Bromide, NDA020414), Surgeon General-Department of the Army (TSG-DA), effective December 23, 2025 (SPL set 0b296555-c32f-42db-b5f3-ea981a3dd2f8), via openFDA
Source: FDA drug label (Mestinon), Bausch Health US, LLC, effective December 2, 2020 (SPL set a851795e-b7a8-40c3-9922-5e79d3eb4d92), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pralidoxime | Pyridostigmine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.249 per tablet 60 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once