What the FDA labels say about taking them together
Pralatrexate and sepiapterin
Sepiapterin's FDA label of April 24, 2026 names pralatrexate in its drug interactions section; the pralatrexate label PlainMeds reads does not name sepiapterin. The sepiapterin label: “DRUG INTERACTIONS Dihydrofolate Reductase (DHFR) Inhibitors: Avoid concomitant use. Sepiapterin Reductase (SR) Inhibitors:”
Check it at the source: the pralatrexate FDA label on DailyMed (effective November 15, 2022, Fresenius Kabi USA, LLC); the sepiapterin FDA label on DailyMed (effective April 24, 2026, PTC Therapeutics Inc.).
What does the pralatrexate label say about sepiapterin?
Pralatrexate's label (effective November 15, 2022) does not name sepiapterin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Pralatrexate), NDA022468 (Acrotech Biopharma), as published by Fresenius Kabi USA, LLC, effective November 15, 2022 (SPL set a5daa583-4965-4564-ad87-41ffe6c08a11), via openFDA; the full label on DailyMed
What does the sepiapterin label say about pralatrexate?
Sepiapterin label, drug interactionsDRUG INTERACTIONS Dihydrofolate Reductase (DHFR) Inhibitors: Avoid concomitant use (e.g., trimethoprim, methotrexate, trimetrexate, pemetrexed, pralatrexate, raltitrexed, or piritrexim). ( 7.1 ) Sepiapterin Reductase (SR) Inhibitors:
Source: FDA drug label (Sephience), PTC Therapeutics Inc., effective April 24, 2026 (SPL set 32ac719c-49f0-4105-9c46-18c19583a5c2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pralatrexate | Sepiapterin | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once