Potassium Citrate and Spironolactone Interaction
Drug interaction information between Potassium Citrate and Spironolactone.
Potassium Citrate and Spironolactone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Potassium Citrate and Spironolactone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications cause the body to hold onto potassium, which can lead to dangerously high levels in the blood.
FDA Label Information
7 DRUG INTERACTIONS The following drug interactions may occur with potassium citrate: Potassium-sparing diuretics: concomitant administration should be avoided since the simultaneous administration of these agents can produce severe hyperkalemia (7.1) Drugs that slow gastrointestinal transit time: These agents (such as anticholinergics) can be expected to increase the gastrointestinal irritation produced by potassium salts (7.2) Renin-angiotensin-aldosterone inhibitors: Monitor for hyperkalemia (7.3) Nonsteroidal Anti-inflammatory drugs (NSAIDs) monitor for hyperkalemia (7.4) 7.1 Potential...
Potassium Citrate Also Interacts With
- Amiloride minor
- Eplerenone minor
- Aliskiren minor
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
What SPL severity band is on file for Potassium Citrate + Spironolactone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Spironolactone has 23 labeled pairs on file vs Potassium Citrate's 4. In the minor band specifically: Potassium Citrate has 4 (also Amiloride, Eplerenone, Aliskiren); Spironolactone has 14 (also Digoxin, Cholestyramine, Amlodipine/Valsartan, Enalapril).
What mechanism field is on file for Potassium Citrate and Spironolactone?
Both of these medications cause the body to hold onto potassium, which can lead to dangerously high levels in the blood.
Spironolactone's labeled portfolio outnumbers Potassium Citrate
SPL source-record counts only. This page's band is minor · classes on file: Potassium Citrate (Urinary Alkalinizer); Spironolactone (Potassium-Sparing Diuretic / Aldosterone Antagonist).
0 major · 0 moderate · 4 minor · 4 total
- Other minor peers for Potassium Citrate
- Amiloride
- Eplerenone
- Aliskiren
0 major · 9 moderate · 14 minor · 23 total
- Other minor peers for Spironolactone
- Digoxin
- Cholestyramine
- Amlodipine/Valsartan
- Enalapril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.