Potassium Citrate and Aliskiren Interaction
Drug interaction information between Potassium Citrate and Aliskiren.
Potassium Citrate and Aliskiren have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Potassium Citrate and Aliskiren. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Aliskiren blocks a hormone that helps the body get rid of potassium, which can lead to a buildup when combined with potassium citrate.
FDA Label Information
7.3 Renin-Angiotensin-Aldosterone System Inhibitors Drugs that inhibit the renin-angiotensin-aldosterone system (RAAS) including angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), spironolactone, eplerenone, or aliskiren produce potassium retention by inhibiting aldosterone production.
Potassium Citrate Also Interacts With
- Spironolactone minor
- Amiloride minor
- Eplerenone minor
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
Frequently Asked Questions
What SPL severity band is on file for Potassium Citrate + Aliskiren?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Potassium Citrate's 4. In the minor band specifically: Potassium Citrate has 4 (also Spironolactone, Amiloride, Eplerenone); Aliskiren has 3 (also Furosemide, Potassium Chloride).
What mechanism field is on file for Potassium Citrate and Aliskiren?
Aliskiren blocks a hormone that helps the body get rid of potassium, which can lead to a buildup when combined with potassium citrate.
Aliskiren carries more major-labeled pairs than Potassium Citrate
SPL source-record counts only. This page's band is minor · classes on file: Potassium Citrate (Urinary Alkalinizer); Aliskiren (Direct Renin Inhibitor).
Aliskiren has 22 major-labeled pairs vs Potassium Citrate's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 4 minor · 4 total
- Other minor peers for Potassium Citrate
- Spironolactone
- Amiloride
- Eplerenone
22 major · 3 moderate · 3 minor · 28 total
- Other minor peers for Aliskiren
- Furosemide
- Potassium Chloride
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.