What the FDA labels say about taking them together
Posaconazole and venetoclax
Posaconazole's FDA label of August 3, 2026 names venetoclax in its contraindications section; the venetoclax label PlainMeds reads does not name posaconazole. The posaconazole label: “… Reductase Inhibitors Primarily Metabolized through CYP3A4 Ergot alkaloids Venetoclax:”
Check it at the source: the posaconazole FDA label on DailyMed (effective August 3, 2026, Aurobindo Pharma Limited); the venetoclax FDA label on DailyMed (effective May 20, 2026, AbbVie Inc.).
What does the posaconazole label say about venetoclax?
Posaconazole label, contraindicationsSirolimus ( 4.2 , 7.2 ) CYP3A4 substrates (pimozide, quinidine): can result in QTc interval prolongation and cases of torsades de pointes (TdP) ( 4.3 , 5.2 , 7.2 ) HMG-CoA Reductase Inhibitors Primarily Metabolized through CYP3A4 ( 4.4 , 7.2 ) Ergot alkaloids ( 4.5 , 7.2 ) Venetoclax:
Posaconazole label, drug interactionsPrevention or Management Venetoclax CLL/SLL patients: Concomitant use of posaconazole with venetoclax during initiation and ramp-up phase is contraindicated.
Posaconazole label, warnings and precautionsConcomitant administration of posaconazole with venetoclax may increase venetoclax toxicities, including the risk of tumor lysis syndrome, neutropenia, and serious infections; monitor for toxicity and reduce venetoclax dose.
Source: FDA drug label (Noxafil, NDA022003), Merck Sharp & Dohme LLC, effective February 13, 2026 (SPL set b073b082-7b57-4423-8c06-4fd4263d6f84), via openFDA
Source: FDA drug label (POSACONAZOLE), Aurobindo Pharma Limited, effective August 3, 2026 (SPL set f8a26673-261c-4e8e-b1e1-9e23aaf7f285), via openFDA; the full label on DailyMed
What does the venetoclax label say about posaconazole?
Venetoclax's label (effective May 20, 2026) does not name posaconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Venclexta), AbbVie Inc., effective May 20, 2026 (SPL set b118a40d-6b56-cee3-10f6-ded821a97018), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Posaconazole | Venetoclax | |
|---|---|---|
| Labeled for | Fungal infections | Leukemia, lymphoma and myeloma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $2.03 per tablet 100 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once