What the FDA labels say about taking them together
Posaconazole and trabectedin
Trabectedin's FDA label (Yondelis) of January 6, 2026 names posaconazole in its drug interactions section; the posaconazole labels PlainMeds reads (2) do not name trabectedin. The trabectedin label: “Avoid using strong CYP3A inhibitors in patients taking YONDELIS.”
Check it at the source: the posaconazole FDA label on DailyMed (effective August 3, 2026, Aurobindo Pharma Limited); the trabectedin FDA label on DailyMed (effective June 29, 2026, Apotex Corp.).
What does the posaconazole label say about trabectedin?
Posaconazole's label (effective August 3, 2026) and its 1 other brand-application label do not name trabectedin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (POSACONAZOLE), Aurobindo Pharma Limited, effective August 3, 2026 (SPL set f8a26673-261c-4e8e-b1e1-9e23aaf7f285), via openFDA; the full label on DailyMed
What does the trabectedin label say about posaconazole?
Yondelis label (Janssen Products, LP, January 6, 2026), drug interactionsAvoid using strong CYP3A inhibitors (e.g., oral ketoconazole, itraconazole, posaconazole, voriconazole, clarithromycin, telithromycin, indinavir, lopinavir, ritonavir, boceprevir, nelfinavir, saquinavir, telaprevir, nefazodone, conivaptan) in patients taking YONDELIS.
Source: FDA drug label (Yondelis, NDA207953), Janssen Products, LP, effective January 6, 2026 (SPL set 472bd78e-be17-4b9d-90f4-9482c3aec9ff), via openFDA
Source: FDA drug label (EVDI), Apotex Corp., effective June 29, 2026 (SPL set c1d50f5c-4202-27f3-4798-a9708114ddea), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Posaconazole | Trabectedin | |
|---|---|---|
| Labeled for | Fungal infections | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $2.03 per tablet 100 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once