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What the FDA labels say about taking them together

Ponesimod and quinidine

Ponesimod's FDA label of December 4, 2025 names quinidine in its drug interactions section; the quinidine label PlainMeds reads does not name ponesimod.

Check it at the source: the ponesimod FDA label on DailyMed (effective December 4, 2025, Vanda Pharmaceuticals Inc.); the quinidine FDA label on DailyMed (effective February 1, 2018, Sun Pharmaceutical Industries, Inc.).

What does the ponesimod label say about quinidine?

Ponesimod label, drug interactions

Class Ia (e.g., quinidine, procainamide) and Class III (e.g., amiodarone, sotalol) anti-arrhythmic drugs have been associated with cases of Torsades de Pointes in patients with bradycardia.

Source: FDA drug label (PONVORY), Vanda Pharmaceuticals Inc., effective December 4, 2025 (SPL set 0c025ba8-ba51-272e-e063-6294a90ad120), via openFDA; the full label on DailyMed

What does the quinidine label say about ponesimod?

Quinidine's label (effective February 1, 2018) does not name ponesimod in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Quinidine Gluconate), Sun Pharmaceutical Industries, Inc., effective February 1, 2018 (SPL set 5023f053-fcc4-4c2c-aa59-9ec198ad185e), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

0Ponesimod generic labelers
4Quinidine generic labelers
PonesimodQuinidine
Labeled forMultiple sclerosisAtrial fibrillation
Boxed warningNoYes
Pharmacy cost (NADAC)n/a$4.92 per tablet 324 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?