What the FDA labels say about taking them together
Ponesimod and procainamide
Ponesimod's FDA label of December 4, 2025 names procainamide in its drug interactions section; the procainamide label PlainMeds reads does not name ponesimod.
Check it at the source: the ponesimod FDA label on DailyMed (effective December 4, 2025, Vanda Pharmaceuticals Inc.); the procainamide FDA label on DailyMed (effective February 17, 2025, Caplin Steriles Limited).
What does the ponesimod label say about procainamide?
Ponesimod label, drug interactionsClass Ia (e.g., quinidine, procainamide) and Class III (e.g., amiodarone, sotalol) anti-arrhythmic drugs have been associated with cases of Torsades de Pointes in patients with bradycardia.
Source: FDA drug label (PONVORY), Vanda Pharmaceuticals Inc., effective December 4, 2025 (SPL set 0c025ba8-ba51-272e-e063-6294a90ad120), via openFDA; the full label on DailyMed
What does the procainamide label say about ponesimod?
Procainamide's label (effective February 17, 2025) does not name ponesimod in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Procainamide Hydrochloride), Caplin Steriles Limited, effective February 17, 2025 (SPL set fcaa5e9a-3c8a-4796-aa87-626268b6cf60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ponesimod | Procainamide | |
|---|---|---|
| Labeled for | Multiple sclerosis | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once