What the FDA labels say about taking them together
Pivmecillinam and valproic acid
Pivmecillinam's FDA label of October 10, 2025 names valproic acid in its drug interactions section; the valproic acid label PlainMeds reads does not name pivmecillinam. The pivmecillinam label: “DRUG INTERACTIONS 7.1 Other Pivalate-Generating Drugs Avoid concurrent treatment with valproic acid, valproate, or other pivalate-generating drugs.”
Check it at the source: the pivmecillinam FDA label on DailyMed (effective October 10, 2025, Alembic Pharmaceuticals Inc.); the valproic acid FDA label on DailyMed (effective January 24, 2025, PAI Holdings, LLC dba PAI Pharma).
What does the pivmecillinam label say about valproic acid?
Pivmecillinam label, drug interactionsDRUG INTERACTIONS 7.1 Other Pivalate-Generating Drugs Avoid concurrent treatment with valproic acid, valproate, or other pivalate-generating drugs.
Pivmecillinam label, warnings and precautionsAvoid concurrent treatment with valproic acid, valproate or other pivalate-generating drugs due to increased risk of carnitine depletion. ( 5.3 ) Clostridioides difficile -Associated Diarrhea (CDAD):
Source: FDA drug label (PIVYA), Alembic Pharmaceuticals Inc., effective October 10, 2025 (SPL set 440a5f17-ab11-0fc8-e063-6394a90a58e9), via openFDA; the full label on DailyMed
What does the valproic acid label say about pivmecillinam?
Valproic acid's label (effective January 24, 2025) does not name pivmecillinam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VALPROIC ACID), PAI Holdings, LLC dba PAI Pharma, effective January 24, 2025 (SPL set 7d5cb52e-37dd-4dfa-a6f4-09f9548846c6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pivmecillinam | Valproic acid | |
|---|---|---|
| Labeled for | Urinary tract infections | Seizures and epilepsy, Migraine |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.243 per capsule 250 mg capsule |
| Shortage now | No current entry | Listed; available |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once