What the FDA labels say about taking them together
Piperacillin/tazobactam and vecuronium
Piperacillin/tazobactam's FDA label of July 21, 2025 names vecuronium in its drug interactions section; the vecuronium label PlainMeds reads does not name piperacillin/tazobactam. The piperacillin/tazobactam label: “… anticoagulants. Piperacillin and tazobactam may prolong the neuromuscular blockade of vecuronium and other non-depolarizing muscle relaxants.”
Check it at the source: the piperacillin/tazobactam FDA label on DailyMed (effective July 21, 2025, ONESOURCE SPECIALTY PHARMA LIMITED); the vecuronium FDA label on DailyMed (effective June 18, 2025, Meitheal Pharmaceuticals Inc.).
What does the piperacillin/tazobactam label say about vecuronium?
Piperacillin/tazobactam label, drug interactionsMonitor kidney function in patients receiving piperacillin and tazobactam and vancomycin. ( 7.3 ) Monitor coagulation parameters in patients receiving piperacillin and tazobactam and heparin or oral anticoagulants. ( 7.4 ) Piperacillin and tazobactam may prolong the neuromuscular blockade of vecuronium and other non-depolarizing muscle relaxants.
Zosyn label (Baxter Healthcare Corporation, May 15, 2026), drug interactionsZOSYN may prolong the neuromuscular blockade of vecuronium and other non-depolarizing neuromuscular blockers.
Piperacillin And Tazobactam And Sodium Chloride label (B. Braun Medical Inc., May 8, 2026), drug interactionsMonitor kidney function in patients receiving Piperacillin and Tazobactam for Injection and Sodium Chloride Injection and vancomycin. ( 7.3 ) Monitor coagulation parameters in patients receiving Piperacillin and Tazobactam for Injection and Sodium Chloride Injection and heparin or oral anticoagulants. ( 7.4 ) Piperacillin and Tazobactam for Injection and Sodium Chloride Injection may prolong the neuromuscular blockade of vecuronium and other non-depolarizing neuromuscular blockers.
Source: FDA drug label (Zosyn, NDA050750), Baxter Healthcare Corporation, effective May 15, 2026 (SPL set 8db6bd91-2106-4bfd-8cc8-38aaf1e18d17), via openFDA
Source: FDA drug label (Piperacillin And Tazobactam And Sodium Chloride, NDA206056), B. Braun Medical Inc., effective May 8, 2026 (SPL set a63ca653-27d4-45fe-a744-77e0efe45220), via openFDA
Source: FDA drug label (piperacillin and tazobactam), ONESOURCE SPECIALTY PHARMA LIMITED, effective July 21, 2025 (SPL set 28258745-12e4-4f0f-b318-4a1a1bebc928), via openFDA; the full label on DailyMed
What does the vecuronium label say about piperacillin/tazobactam?
Vecuronium's label (effective June 18, 2025) does not name piperacillin/tazobactam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Vecuronium Bromide), Meitheal Pharmaceuticals Inc., effective June 18, 2025 (SPL set 53653418-0464-4cd2-a987-3d31be36098f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Piperacillin/tazobactam | Vecuronium | |
|---|---|---|
| Labeled for | Bacterial infections | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $3.49 per vial 3.375 g vial | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once