What the FDA labels say about taking them together
Pioglitazone and teriflunomide
Teriflunomide's FDA label of February 20, 2026 names pioglitazone in its drug interactions section; the pioglitazone label PlainMeds reads does not name teriflunomide. The teriflunomide label: “In patients taking AUBAGIO, exposure of drugs metabolized by CYP2C8 may be increased.”
Check it at the source: the pioglitazone FDA label on DailyMed (effective March 28, 2025, Takeda Pharmaceuticals America, Inc.); the teriflunomide FDA label on DailyMed (effective February 20, 2026, Genzyme Corporation).
What does the pioglitazone label say about teriflunomide?
Pioglitazone's label (effective March 28, 2025) does not name teriflunomide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Actos), Takeda Pharmaceuticals America, Inc., effective March 28, 2025 (SPL set d2ddc491-88a9-4063-9150-443b4fa4330c), via openFDA; the full label on DailyMed
What does the teriflunomide label say about pioglitazone?
Teriflunomide label, drug interactionsIn patients taking AUBAGIO, exposure of drugs metabolized by CYP2C8 (e.g., paclitaxel, pioglitazone, repaglinide, rosiglitazone) may be increased.
Source: FDA drug label (Aubagio), NDA202992 (Sanofi Aventis Us), as published by Genzyme Corporation, effective February 20, 2026 (SPL set 4650d12c-b9c8-4525-b07f-a2d773eca155), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pioglitazone | Teriflunomide | |
|---|---|---|
| Labeled for | Type 2 diabetes | Multiple sclerosis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0675 per tablet 15 mg tablet | $0.233 per tablet 14 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once