What the FDA labels say about taking them together
Pioglitazone and sulfamethoxazole/trimethoprim
Sulfamethoxazole/trimethoprim's FDA label of December 30, 2024 names pioglitazone in its drug interactions section; the pioglitazone label PlainMeds reads does not name sulfamethoxazole/trimethoprim. The sulfamethoxazole/trimethoprim label: “Monitor blood glucose more frequently; Comments: Like other sulfonamide-containing drugs, BACTRIM potentiates the effect of oral hypoglycemic that are metabolized by CYP2C8 or CYP2C9 or eliminated renally via OCT2 …”
Check it at the source: the pioglitazone FDA label on DailyMed (effective March 28, 2025, Takeda Pharmaceuticals America, Inc.); the sulfamethoxazole/trimethoprim FDA label on DailyMed (effective December 30, 2024, Sun Pharmaceutical Industries, Inc).
What does the pioglitazone label say about sulfamethoxazole/trimethoprim?
Pioglitazone's label (effective March 28, 2025) does not name sulfamethoxazole/trimethoprim in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Actos), Takeda Pharmaceuticals America, Inc., effective March 28, 2025 (SPL set d2ddc491-88a9-4063-9150-443b4fa4330c), via openFDA; the full label on DailyMed
What does the sulfamethoxazole/trimethoprim label say about pioglitazone?
Sulfamethoxazole/trimethoprim label, drug interactionsDrug (s): Oral Hypoglycemics; Recommendation: Monitor blood glucose more frequently; Comments: Like other sulfonamide-containing drugs, BACTRIM potentiates the effect of oral hypoglycemic that are metabolized by CYP2C8 (e.g., pioglitazone, repaglinide, and rosiglitazone) or CYP2C9 (e.g., glipizide and glyburide) or eliminated renally via OCT2 (e.g., metformin). Additional monitoring of blood glucose may be warranted.
Source: FDA drug label (Bactrim), Sun Pharmaceutical Industries, Inc, effective December 30, 2024 (SPL set f59d0c04-9c66-4d53-a0e1-cb55570deb62), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pioglitazone | Sulfamethoxazole/trimethoprim | |
|---|---|---|
| Labeled for | Type 2 diabetes | Bacterial infections, Urinary tract infections, Diarrhea |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0675 per tablet 15 mg tablet | $0.0448 per tablet Sulfamethoxazole-tmp ds tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once