What the FDA labels say about taking them together
Pimozide and zileuton
Pimozide's FDA label of August 12, 2026 names zileuton in its contraindications section; the zileuton labels PlainMeds reads (2) do not name pimozide.
Check it at the source: the pimozide FDA label on DailyMed (effective August 12, 2026, Par Health USA, LLC); the zileuton FDA label on DailyMed (effective July 29, 2022, Strides Pharma Science Limited).
What does the pimozide label say about zileuton?
Pimozide label, contraindicationsOther drugs that are relatively less potent inhibitors of CYP 3A4 should also be avoided, in view of the risks: e.g., zileuton, fluvoxamine.
Source: FDA drug label (Pimozide), Par Health USA, LLC, effective August 12, 2026 (SPL set 70b079e2-a1f7-4a93-8685-d60a4d7c1280), via openFDA; the full label on DailyMed
What does the zileuton label say about pimozide?
Zileuton's label (effective July 29, 2022) and its 1 other brand-application label do not name pimozide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zileuton), Strides Pharma Science Limited, effective July 29, 2022 (SPL set a826d16f-df07-447b-b050-b9a02ea1f89e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pimozide | Zileuton | |
|---|---|---|
| Labeled for | n/a | Asthma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.23 per tablet 1 mg tablet | $2.05 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once