Pimozide and Sotalol Interaction
Drug interaction information between Pimozide and Sotalol.
Pimozide and Sotalol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pimozide and Sotalol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can interfere with the heart's electrical cycle in the same way. This increases the chance of developing a severe and dangerous heart rhythm.
FDA Label Information
Accordingly, pimozide should not be given with dofetilide, sotalol, quinidine, other Class Ia and III anti-arrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol, tacrolimus, ziprasidone, or other drugs that have demonstrated QT prolongation as one of their pharmacodynamic effects.
Pimozide Also Interacts With
- Aprepitant major
- Citalopram major
- Clarithromycin major
- Darunavir major
- Escitalopram major
Sotalol Also Interacts With
- Clonidine moderate
- Amiodarone moderate
- Clarithromycin moderate
- Digoxin moderate
- Albuterol minor
Frequently Asked Questions
What SPL severity band is on file for Pimozide + Sotalol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pimozide has 24 labeled pairs on file vs Sotalol's 13. In the minor band specifically: Pimozide has 12 (also Moxifloxacin, Ziprasidone, Chlorpromazine, Thioridazine); Sotalol has 9 (also Albuterol, Diltiazem, Verapamil, Clozapine).
What mechanism field is on file for Pimozide and Sotalol?
Both drugs can interfere with the heart's electrical cycle in the same way. This increases the chance of developing a severe and dangerous heart rhythm.
Pimozide carries more major-labeled pairs than Sotalol
SPL source-record counts only. This page's band is minor · classes on file: Pimozide (Typical Antipsychotic); Sotalol (Class III Antiarrhythmic / Beta-Blocker).
Pimozide has 12 major-labeled pairs vs Sotalol's 0. This page itself is in the minor band, not the major band.
12 major · 0 moderate · 12 minor · 24 total
- Other minor peers for Pimozide
- Moxifloxacin
- Ziprasidone
- Chlorpromazine
- Thioridazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.