What the FDA labels say about taking them together
Phenylephrine and selegiline
Phenylephrine's FDA label of August 19, 2026 names selegiline in its drug interactions section, and selegiline's label names phenylephrine too. The phenylephrine label: “The pressor effect of phenylephrine hydrochloride is increased in patients receiving: Monoamine oxidase inhibitors (MAOI), such as selegiline. …”
Check it at the source: the phenylephrine FDA label on DailyMed (effective August 19, 2026, Hikma Pharmaceuticals USA Inc.); the selegiline FDA label on DailyMed (effective August 7, 2024, Rising Pharma Holdings, Inc.).
What does the phenylephrine label say about selegiline?
Phenylephrine label, drug interactionsThe pressor effect of phenylephrine hydrochloride is increased in patients receiving: Monoamine oxidase inhibitors (MAOI), such as selegiline. β-adrenergic blockers α-2 adrenergic agonists, such as clonidine Steroids Tricyclic antidepressants Norepinephrine transport inhibitors, such as atomoxetine Ergot alkaloids, such as methylergonovine maleate Centrally-acting sympatholytic agents, such as guanfacine or reserpine Atropine sulfate
Source: FDA drug label (Phenylephrine Hydrochloride), Hikma Pharmaceuticals USA Inc., effective August 19, 2026 (SPL set e1a7ab4b-0afe-4463-a039-5be0323cf2f7), via openFDA; the full label on DailyMed
What does the selegiline label say about phenylephrine?
Emsam label (Viatris Specialty LLC, May 15, 2020), drug interactionsTherefore, monitor blood pressure if EMSAM is used with any of the following drugs: buspirone, amphetamines, and cold products or weight-reducing preparations that contain sympathomimetic amines (e.g., pseudoephedrine, phenylephrine, phenylpropanolamine, and ephedrine).
Emsam label (Viatris Specialty LLC, May 15, 2020), warnings and precautionsBlood Pressure Elevation Related to Concomitant Medication: monitor blood pressure if EMSAM is used with any of the following drugs: buspirone, amphetamines, or cold products or weight-reducing preparations that contain sympathomimetic amines (e.g., pseudoephedrine, phenylephrine, phenylpropanolamine, and ephedrine).
Source: FDA drug label (Emsam, NDA021336), Viatris Specialty LLC, effective May 15, 2020 (SPL set b891bd9f-fdb8-4862-89c5-ecdd700398a3), via openFDA
Source: FDA drug label (Selegiline Hydrochloride), Rising Pharma Holdings, Inc., effective August 7, 2024 (SPL set 23c4481f-d150-40c6-addb-b3e454ca914f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Phenylephrine | Selegiline | |
|---|---|---|
| Labeled for | Cough and cold, Allergies | Parkinson's disease, Depression |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $5.24 per mL 10% eye drop | $0.756 per capsule 5 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once