What the FDA labels say about taking them together
Oxcarbazepine and perampanel
Perampanel's FDA label of September 1, 2024 names oxcarbazepine in its drug interactions section; the oxcarbazepine labels PlainMeds reads (2) do not name perampanel. The perampanel label: “DRUG INTERACTIONS Contraceptives: 12 mg once daily may decrease the effectiveness of hormonal contraceptives containing levonorgestrel Moderate and Strong CYP3A4 Inducers: increase clearance of perampanel and decrease …”
Check it at the source: the oxcarbazepine FDA label on DailyMed (effective December 16, 2025, Novartis Pharmaceuticals Corporation); the perampanel FDA label on DailyMed (effective September 1, 2024, Teva Pharmaceuticals, Inc.).
What does the oxcarbazepine label say about perampanel?
Oxcarbazepine's label (effective December 16, 2025) and its 1 other brand-application label do not name perampanel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Trileptal), Novartis Pharmaceuticals Corporation, effective December 16, 2025 (SPL set 4c5c86c8-ab7f-4fcf-bc1b-5a0b1fd0691b), via openFDA; the full label on DailyMed
What does the perampanel label say about oxcarbazepine?
Perampanel label, drug interactionsDRUG INTERACTIONS Contraceptives: 12 mg once daily may decrease the effectiveness of hormonal contraceptives containing levonorgestrel ( 7.1 ) Moderate and Strong CYP3A4 Inducers (including carbamazepine, oxcarbazepine, and phenytoin): increase clearance of perampanel and decrease perampanel plasma concentrations.
Source: FDA drug label (Perampanel), Teva Pharmaceuticals, Inc., effective September 1, 2024 (SPL set bc8f7cf2-c19c-4235-859f-9ff1dd21908e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Oxcarbazepine | Perampanel | |
|---|---|---|
| Labeled for | Seizures and epilepsy | Seizures and epilepsy |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.167 per tablet 300 mg tablet | $14.43 per tablet 4 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once