What the FDA labels say about taking them together
Peginterferon alfa 2a and zidovudine
Peginterferon alfa 2a's FDA label of September 2, 2026 names zidovudine in its drug interactions section; the zidovudine labels PlainMeds reads (3) do not name peginterferon alfa 2a. The peginterferon alfa 2a label: “Reduce or discontinue the dose of PEGASYS or ribavirin or both should the events worsen Zidovudine: monitor for worsening neutropenia and/or anemia with PEGASYS and/or ribavirin”
Check it at the source: the peginterferon alfa 2a FDA label on DailyMed (effective September 2, 2026); the zidovudine FDA label on DailyMed (effective February 10, 2025, Aurobindo Pharma Limited).
What does the peginterferon alfa 2a label say about zidovudine?
Peginterferon alfa 2a label, drug interactionsReduce or discontinue the dose of PEGASYS or ribavirin or both should the events worsen ( 7.4 ) Zidovudine: monitor for worsening neutropenia and/or anemia with PEGASYS and/or ribavirin
Peginterferon alfa 2a label, warnings and precautionsAll 14 subjects were on NRTIs, including stavudine, didanosine, abacavir, zidovudine, and lamivudine.
Source: FDA drug label (Pegasys), pharmaand GmbH, effective September 2, 2026 (SPL set d9290e5b-6d40-2318-e053-2995a90a9916), via openFDA; the full label on DailyMed
What does the zidovudine label say about peginterferon alfa 2a?
Zidovudine's label (effective February 10, 2025) and its 2 other brand-application labels do not name peginterferon alfa 2a in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zidovudine), Aurobindo Pharma Limited, effective February 10, 2025 (SPL set 51abd2ce-6be1-412d-b806-5f24935ac5e3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Peginterferon alfa 2a | Zidovudine | |
|---|---|---|
| Labeled for | Hepatitis C, Hepatitis B | HIV |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.464 per tablet 300 mg tablet |
| Shortage now | Resolved | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once