What the FDA labels say about taking them together
Pazopanib and simvastatin
Pazopanib's FDA label of December 16, 2025 names simvastatin in its drug interactions section; the simvastatin label PlainMeds reads does not name pazopanib. The pazopanib label: “Concomitant use of VOTRIENT with simvastatin increases the risk of alanine aminotransferase (ALT) elevations.”
Check it at the source: the pazopanib FDA label on DailyMed (effective December 16, 2025, Novartis Pharmaceuticals Corporation); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the pazopanib label say about simvastatin?
Pazopanib label, drug interactionsConcomitant use of VOTRIENT with simvastatin increases the risk of alanine aminotransferase (ALT) elevations.
Pazopanib label, warnings and precautionsConcomitant Use of Simvastatin Concomitant use of VOTRIENT and simvastatin increases the risk of ALT elevations [see Drug Interactions (7.3)].
Source: FDA drug label (VOTRIENT), Novartis Pharmaceuticals Corporation, effective December 16, 2025 (SPL set eeaaaf38-fb86-4d9f-a19d-0f61daac2fd7), via openFDA; the full label on DailyMed
What does the simvastatin label say about pazopanib?
Simvastatin's label (effective March 28, 2025) does not name pazopanib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pazopanib | Simvastatin | |
|---|---|---|
| Labeled for | n/a | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.0321 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once