What the FDA labels say about taking them together
Paroxetine and theophylline
Paroxetine's FDA label (Brisdelle) of April 28, 2025 names theophylline in its drug interactions section; the theophylline label PlainMeds reads does not name paroxetine. The paroxetine label: “Theophylline Increased plasma concentrations of theophylline The theophylline dosage of may need to be decreased. Monitor theophylline concentrations and tolerability.”
Check it at the source: the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.); the theophylline FDA label on DailyMed (effective March 10, 2026, Strides Pharma Science Limited).
What does the paroxetine label say about theophylline?
Brisdelle label (Legacy Pharma USA, Inc., April 28, 2025), drug interactionsTheophylline Increased plasma concentrations of theophylline The theophylline dosage of may need to be decreased. Monitor theophylline concentrations and tolerability.
Source: FDA drug label (Brisdelle, NDA204516), Legacy Pharma USA, Inc., effective April 28, 2025 (SPL set 502311b3-b617-4cbd-a3ab-a60f2c62880a), via openFDA
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
What does the theophylline label say about paroxetine?
Theophylline's label (effective March 10, 2026) does not name paroxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Theophylline), Strides Pharma Science Limited, effective March 10, 2026 (SPL set b7a90ccf-9c32-40cc-9008-7e55b3da4dfd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Paroxetine | Theophylline | |
|---|---|---|
| Labeled for | Depression, Anxiety, Menopause symptoms | Asthma |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0611 per tablet 20 mg tablet | $0.330 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once