What the FDA labels say about taking them together
Paroxetine and quinine
Quinine's FDA label of November 9, 2023 names paroxetine in its drug interactions (prescription label) section; the paroxetine labels PlainMeds reads (4) do not name quinine.
Check it at the source: the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.); the quinine FDA label on DailyMed (effective November 9, 2023).
What does the paroxetine label say about quinine?
Paroxetine's label (effective February 12, 2026) and its 3 other brand-application labels do not name quinine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
What does the quinine label say about paroxetine?
Quinine label, drug interactions (prescription label)Although clinical drug interaction studies have not been performed, antimalarial doses (greater than or equal to 600 mg) of quinine may inhibit the metabolism of other drugs that are CYP2D6 substrates (e.g., flecainide, debrisoquine, dextromethorphan, metoprolol, paroxetine ).
Source: FDA drug label (Chininum sulphuricum), Boiron, effective November 9, 2023 (SPL set 33885950-2a55-11e7-8288-424c58303031), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Paroxetine | Quinine | |
|---|---|---|
| Labeled for | Depression, Anxiety, Menopause symptoms | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0611 per tablet 20 mg tablet | $0.698 per capsule 324 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once