What the FDA labels say about taking them together
Flecainide and paroxetine
Paroxetine's FDA label of February 12, 2026 names flecainide in its drug interactions section; the flecainide label PlainMeds reads does not name paroxetine.
Check it at the source: the flecainide FDA label on DailyMed (effective June 11, 2026, Amneal Pharmaceuticals of New York LLC); the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.).
What does the flecainide label say about paroxetine?
Flecainide's label (effective June 11, 2026) does not name paroxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Flecainide Acetate), Amneal Pharmaceuticals of New York LLC, effective June 11, 2026 (SPL set ee9595d5-08a1-4529-9215-ddc3c7f929c4), via openFDA; the full label on DailyMed
What does the paroxetine label say about flecainide?
Paroxetine label, drug interactionsExamples; propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine, venlafaxine, risperidone.
Brisdelle label (Legacy Pharma USA, Inc., April 28, 2025), drug interactionsUse caution with concomitant use of BRISDELLE with other drugs that are metabolized by CYP2D6, including nortriptyline, amitriptyline, imipramine, desipramine, fluoxetine, phenothiazines, risperidone, and Type 1C antiarrhythmics (e.g., propafenone, flecainide, and encainide).
Source: FDA drug label (Brisdelle, NDA204516), Legacy Pharma USA, Inc., effective April 28, 2025 (SPL set 502311b3-b617-4cbd-a3ab-a60f2c62880a), via openFDA
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Flecainide | Paroxetine | |
|---|---|---|
| Labeled for | n/a | Depression, Anxiety, Menopause symptoms |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.171 per tablet 100 mg tablet | $0.0611 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once