What the FDA labels say about taking them together
Dextromethorphan and paroxetine
Paroxetine's FDA label of February 12, 2026 names dextromethorphan in its drug interactions section; the dextromethorphan label PlainMeds reads does not name paroxetine.
Check it at the source: the dextromethorphan FDA label on DailyMed (effective August 27, 2026); the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.).
What does the dextromethorphan label say about paroxetine?
Dextromethorphan's label (effective August 27, 2026) does not name paroxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Good Sense Cough DM), L. Perrigo Company, effective August 27, 2026 (SPL set 5a2e9bef-42cb-4b72-9a26-c3ae71dcb4ea), via openFDA; the full label on DailyMed
What does the paroxetine label say about dextromethorphan?
Paroxetine label, drug interactionsExamples; propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine, venlafaxine, risperidone.
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dextromethorphan | Paroxetine | |
|---|---|---|
| Labeled for | Cough and cold | Depression, Anxiety, Menopause symptoms |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.122 per unit 15 mg softgel | $0.0611 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once