What the FDA labels say about taking them together
Atomoxetine and paroxetine
Atomoxetine's FDA label of May 25, 2026 names paroxetine in its drug interactions section, and paroxetine's label names atomoxetine too. The paroxetine label: “Atomoxetine Increased exposure of atomoxetine A lower atomoxetine dosage of may be necessary. Monitor tolerability.”
Check it at the source: the atomoxetine FDA label on DailyMed (effective May 25, 2026, Camber Pharmaceuticals, Inc.); the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.).
What does the atomoxetine label say about paroxetine?
Atomoxetine label, drug interactionsInhibitors on Atomoxetine In extensive metabolizers (EMs), inhibitors of CYP2D6 (e.g., paroxetine, fluoxetine, and quinidine) increase atomoxetine steady-state plasma concentrations to exposures similar to those observed in poor metabolizers (PMs).
Atomoxetine label, warnings and precautionsDosage adjustment of atomoxetine may be necessary when coadministered with potent CYP2D6 inhibitors (e.g., paroxetine, fluoxetine, and quinidine) or when administered to CYP2D6 PMs. [see Dosage and Administration ( 2.5 ) and Drug Interactions ( 7.2 )].
Source: FDA drug label (Atomoxetine), ANDA202682 (Hetero Labs Ltd V), as published by Camber Pharmaceuticals, Inc., effective May 25, 2026 (SPL set f266ab7b-5a68-42b5-b204-e3249bea0aed), via openFDA; the full label on DailyMed
What does the paroxetine label say about atomoxetine?
Paroxetine label, drug interactionsExamples; propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine, venlafaxine, risperidone.
Brisdelle label (Legacy Pharma USA, Inc., April 28, 2025), drug interactionsAtomoxetine Increased exposure of atomoxetine A lower atomoxetine dosage of may be necessary (see atomoxetine Prescribing Information for). Monitor tolerability.
Source: FDA drug label (Brisdelle, NDA204516), Legacy Pharma USA, Inc., effective April 28, 2025 (SPL set 502311b3-b617-4cbd-a3ab-a60f2c62880a), via openFDA
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atomoxetine | Paroxetine | |
|---|---|---|
| Labeled for | ADHD | Depression, Anxiety, Menopause symptoms |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.442 per capsule 40 mg capsule | $0.0611 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once