What the FDA labels say about taking them together
Paricalcitol and posaconazole
Paricalcitol's FDA label of August 7, 2024 names posaconazole in its drug interactions section; the posaconazole labels PlainMeds reads (2) do not name paricalcitol. The paricalcitol label: “… itraconazole, ketoconazole, lopinavir/ritonavir, mibefradil, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, telithromycin, voriconazole.”
Check it at the source: the paricalcitol FDA label on DailyMed (effective August 7, 2024, AbbVie Inc.); the posaconazole FDA label on DailyMed (effective August 3, 2026, Aurobindo Pharma Limited).
What does the paricalcitol label say about posaconazole?
Paricalcitol label, drug interactionsClinical Impact; Paricalcitol is partially metabolized by CYP3A. Hence, exposure of paricalcitol will increase upon coadministration with strong CYP3A inhibitors such as but not limited to: boceprevir, clarithromycin, conivaptan, grapefruit juice, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, mibefradil, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, telithromycin, voriconazole.
Zemplar label (AbbVie Inc., August 1, 2024), drug interactionsExamples; Boceprevir, clarithromycin, conivaptan, grapefruit juice, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, mibefradil, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telithromycin, and voriconazole
Source: FDA drug label (Zemplar, NDA020819), AbbVie Inc., effective August 1, 2024 (SPL set 7259652f-81bc-4ad1-bba5-d01f9fac1b80), via openFDA
Source: FDA drug label (Paricalcitol, NDA207174), Accord Healthcare, Inc., effective July 30, 2024 (SPL set 2b7c7587-2042-0d9c-e054-00144ff88e88), via openFDA
Source: FDA drug label (Zemplar), AbbVie Inc., effective August 7, 2024 (SPL set 1b27c026-2d60-47b4-2a9c-ded1818f21b5), via openFDA; the full label on DailyMed
What does the posaconazole label say about paricalcitol?
Posaconazole's label (effective August 3, 2026) and its 1 other brand-application label do not name paricalcitol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (POSACONAZOLE), Aurobindo Pharma Limited, effective August 3, 2026 (SPL set f8a26673-261c-4e8e-b1e1-9e23aaf7f285), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Paricalcitol | Posaconazole | |
|---|---|---|
| Labeled for | n/a | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.28 per capsule 1 mcg capsule | $2.03 per tablet 100 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once