What the FDA labels say about taking them together
Pantoprazole and rilpivirine
Pantoprazole's FDA label of May 18, 2026 names rilpivirine in its drug interactions section, and rilpivirine's label names pantoprazole too. The rilpivirine label: “Coadministration is contraindicated with EDURANT or EDURANT PED.”
Check it at the source: the pantoprazole FDA label on DailyMed (effective May 18, 2026, Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.); the rilpivirine FDA label on DailyMed (effective August 28, 2025, Janssen Products, LP).
What does the pantoprazole label say about rilpivirine?
Pantoprazole label, drug interactionsAntiretrovirals Clinical Impact: The effect of PPIs on antiretroviral drugs is variable. The clinical importance and the mechanisms behind these interactions are not always known. • Decreased exposure of some antiretroviral drugs (…) when used concomitantly with pantoprazole may reduce antiviral effect and promote the development of drug resistance. … Intervention: Rilpivirine-containing products: Concomitant use with PROTONIX is contraindicated [see ]. See prescribing information. Atazanavir: See prescribing information for atazanavir for dosing information. Nelfinavir: Avoid concomitant use with PROTONIX. See prescribing information for nelfinavir. …
Source: FDA drug label (Pantoprazole Sodium, NDA209463), Hikma Pharmaceuticals USA Inc., effective July 19, 2023 (SPL set 1e102c44-232b-4aaf-b457-2a740c47193a), via openFDA
Source: FDA drug label (Protonix Delayed-Release), Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., effective May 18, 2026 (SPL set 08098cb2-c048-4640-f387-6beec4a38936), via openFDA; the full label on DailyMed
What does the rilpivirine label say about pantoprazole?
Rilpivirine label, contraindicationsDrug Class: Proton Pump Inhibitors; Contraindicated Drugs in Class: e.g., Esomeprazole Lansoprazole Omeprazole Pantoprazole Rabeprazole; Clinical Comment: Potential for significant decreases in rilpivirine plasma concentrations due to gastric pH increase, which may result in loss of virologic response.
Rilpivirine label, drug interactionsConcomitant Drug Class/Drug Name: Proton Pump Inhibitors: e.g., esomeprazole lansoprazole omeprazole pantoprazole rabeprazole; Effect on Concentration of Rilpivirine or Concomitant Drug: ↓ rilpivirine; Clinical Comment: Coadministration is contraindicated with EDURANT or EDURANT PED [see ].
Source: FDA drug label (EDURANT), Janssen Products, LP, effective August 28, 2025 (SPL set 03880372-2c68-45c6-a53a-f420c49541d6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pantoprazole | Rilpivirine | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0358 per tablet 40 mg tablet | $48.04 per tablet 25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once