What the FDA labels say about taking them together
Paliperidone and rifampin
Paliperidone's FDA label (Invega Sustenna) of February 14, 2025 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name paliperidone. The paliperidone label: “Avoid using CYP3A4 and/or P-gp inducers with INVEGA TRINZA during the 3-month dosing interval, if possible. If administering a strong inducer is necessary, consider managing the patient using paliperidone …”
Check it at the source: the paliperidone FDA label on DailyMed (effective January 31, 2025, Janssen Pharmaceuticals, Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the paliperidone label say about rifampin?
Invega Sustenna label (Janssen Pharmaceuticals, Inc., February 14, 2025), drug interactionsAvoid using a strong inducer of CYP3A4 and/or P-gp (e.g., carbamazepine, rifampin, St John's Wort) during a dosing interval for INVEGA SUSTENNA.
Invega Trinza label (Janssen Pharmaceuticals, Inc, February 14, 2025), drug interactionsConcomitant Drug Name or Drug Class: Strong Inducers of CYP3A4 and P-gp (e.g., carbamazepine, rifampin, or St. John's Wort); Clinical Rationale: The concomitant use of paliperidone and strong inducers of CYP3A4 and P-gp may decrease the exposure of paliperidone [see ].; Clinical Recommendation: Avoid using CYP3A4 and/or P-gp inducers with INVEGA TRINZA during the 3-month dosing interval, if possible. If administering a strong inducer is necessary, consider managing the patient using paliperidone extended-release tablets [see ].
Source: FDA drug label (Invega Sustenna, NDA022264), Janssen Pharmaceuticals, Inc., effective February 14, 2025 (SPL set 1af14e42-951d-414d-8564-5d5fce138554), via openFDA
Source: FDA drug label (Invega Trinza, NDA207946), Janssen Pharmaceuticals, Inc, effective February 14, 2025 (SPL set c39e65d7-fa44-4e4c-8b12-a654d3ed0eae), via openFDA
Source: FDA drug label (INVEGA), Janssen Pharmaceuticals, Inc., effective January 31, 2025 (SPL set 7b8e5b26-b9e4-4704-921b-3c3c0d159916), via openFDA; the full label on DailyMed
What does the rifampin label say about paliperidone?
Rifampin's label (effective February 11, 2026) does not name paliperidone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Paliperidone | Rifampin | |
|---|---|---|
| Labeled for | Schizophrenia | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.972 per tablet 3 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once