What the FDA labels say about taking them together
Paliperidone and procainamide
Paliperidone's FDA label of January 31, 2025 names procainamide in its warnings and precautions section; the procainamide label PlainMeds reads does not name paliperidone.
Check it at the source: the paliperidone FDA label on DailyMed (effective January 31, 2025, Janssen Pharmaceuticals, Inc.); the procainamide FDA label on DailyMed (effective February 17, 2025, Caplin Steriles Limited).
What does the paliperidone label say about procainamide?
Paliperidone label, warnings and precautionsThe use of paliperidone should be avoided in combination with other drugs that are known to prolong QTc including Class 1A (e.g., quinidine, procainamide) or Class III (e.g., amiodarone, sotalol) antiarrhythmic medications, antipsychotic medications (e.g., chlorpromazine, thioridazine), antibiotics (e.g., gatifloxacin, moxifloxacin), or any other class of medications known to prolong the QTc interval.
Source: FDA drug label (INVEGA), Janssen Pharmaceuticals, Inc., effective January 31, 2025 (SPL set 7b8e5b26-b9e4-4704-921b-3c3c0d159916), via openFDA; the full label on DailyMed
What does the procainamide label say about paliperidone?
Procainamide's label (effective February 17, 2025) does not name paliperidone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Procainamide Hydrochloride), Caplin Steriles Limited, effective February 17, 2025 (SPL set fcaa5e9a-3c8a-4796-aa87-626268b6cf60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Paliperidone | Procainamide | |
|---|---|---|
| Labeled for | Schizophrenia | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.972 per tablet 3 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once