What the FDA labels say about taking them together
Palbociclib and posaconazole
Palbociclib's FDA label of July 2, 2026 names posaconazole in its drug interactions section; the posaconazole labels PlainMeds reads (2) do not name palbociclib. The palbociclib label: “Avoid concomitant use of strong CYP3A inhibitors.”
Check it at the source: the palbociclib FDA label on DailyMed (effective July 2, 2026, Pfizer Laboratories Div Pfizer Inc); the posaconazole FDA label on DailyMed (effective August 3, 2026, Aurobindo Pharma Limited).
What does the palbociclib label say about posaconazole?
Palbociclib label, drug interactionsAvoid concomitant use of strong CYP3A inhibitors (e.g., clarithromycin, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, telithromycin, and voriconazole).
Source: FDA drug label (Ibrance), Pfizer Laboratories Div Pfizer Inc, effective July 2, 2026 (SPL set fecbdd7d-b729-41b5-9872-231b8fe104ce), via openFDA; the full label on DailyMed
What does the posaconazole label say about palbociclib?
Posaconazole's label (effective August 3, 2026) and its 1 other brand-application label do not name palbociclib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (POSACONAZOLE), Aurobindo Pharma Limited, effective August 3, 2026 (SPL set f8a26673-261c-4e8e-b1e1-9e23aaf7f285), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Palbociclib | Posaconazole | |
|---|---|---|
| Labeled for | Breast cancer | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $2.03 per tablet 100 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once